BDBM709622 (E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-fluoroazetidine-3- carbonyl)piperidin- 4-yl)-5-methyl- 1H-pyrazol-4-yl)-4- methoxypyrazolo [1,5-a]pyridine-3-carbonitrile::US12180207, Example 153

SMILES COc1cc(-c2cnn(C3CCN(C(=O)C4(F)CN(C(=O)/C=C/CN(C)C)C4)CC3)c2C)cn2ncc(C#N)c12

InChI Key InChIKey=MJMIZDWOYMOFDX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 709622   

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709622((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 210nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM709622((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 11nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709622((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 2nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709622((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 39nMAssay Description:FGFR1 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM709622((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 4nMAssay Description:FGFR2 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709622((E)-6-(1-(1-(1-(4- (dimethylamino)but- 2-enoyl)-3-...)
Affinity DataIC50: 5nMAssay Description:FGFR3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent