BDBM709562 6-(1-(1-((1-acryloyl-3- methoxyazetidin-3- yl)methyl)piperidin-4-yl)- 5-methyl-1H-pyrazol-4- yl)-4- methoxypyrazolo[1,5- a]pyridine-3-carbonitrile::US12180207, Example 91

SMILES C=CC(=O)N1CC(CN2CCC(n3ncc(-c4cc(OC)c5c(C#N)cnn5c4)c3C)CC2)(OC)C1

InChI Key InChIKey=OGQXSEPTYDNHKF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 709562   

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709562(6-(1-(1-((1-acryloyl-3- methoxyazetidin-3- yl)meth...)
Affinity DataIC50: 284nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM709562(6-(1-(1-((1-acryloyl-3- methoxyazetidin-3- yl)meth...)
Affinity DataIC50: 19nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709562(6-(1-(1-((1-acryloyl-3- methoxyazetidin-3- yl)meth...)
Affinity DataIC50: 2nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709562(6-(1-(1-((1-acryloyl-3- methoxyazetidin-3- yl)meth...)
Affinity DataIC50: 197nMAssay Description:FGFR1 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM709562(6-(1-(1-((1-acryloyl-3- methoxyazetidin-3- yl)meth...)
Affinity DataIC50: 99nMAssay Description:FGFR2 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709562(6-(1-(1-((1-acryloyl-3- methoxyazetidin-3- yl)meth...)
Affinity DataIC50: 19nMAssay Description:FGFR3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent