BDBM709533 (S)-6-(1-(1-(1- acryloylpiperidine-4- carbonyl)pyrrolidin-3-yl)- 1H-pyrazol-4-yl)-4- methoxypyrazolo[1,5- a]pyridine-3-carbonitrile::US12180207, Example 62

SMILES C=CC(=O)N1CCC(C(=O)N2CC[C@H](n3cc(-c4cc(OC)c5c(C#N)cnn5c4)cn3)C2)CC1

InChI Key InChIKey=TUKVBIHBLUMARN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 709533   

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709533((S)-6-(1-(1-(1- acryloylpiperidine-4- carbonyl)pyr...)
Affinity DataIC50: 328nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709533((S)-6-(1-(1-(1- acryloylpiperidine-4- carbonyl)pyr...)
Affinity DataIC50: 64nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709533((S)-6-(1-(1-(1- acryloylpiperidine-4- carbonyl)pyr...)
Affinity DataIC50: 18nMAssay Description:FGFR1 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM709533((S)-6-(1-(1-(1- acryloylpiperidine-4- carbonyl)pyr...)
Affinity DataIC50: 5nMAssay Description:FGFR2 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709533((S)-6-(1-(1-(1- acryloylpiperidine-4- carbonyl)pyr...)
Affinity DataIC50: 2nMAssay Description:FGFR3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent