BDBM709517 N-(4-(4-(4-(3-cyano-4- methoxypyrazolo[1,5- a]pyridin-6-yl)-1H- pyrazol-1-yl)piperidine-1- carbonyl)bicyclo[1.1.1] pentan-2-yl)acrylamide::US12180207, Example 46

SMILES C=CC(=O)NC1C2CC1C2C(=O)N1CCC(n2cc(-c3cc(OC)c4c(C#N)cnn4c3)cn2)CC1

InChI Key InChIKey=XORAFTFBTLPFEB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 709517   

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709517(N-(4-(4-(4-(3-cyano-4- methoxypyrazolo[1,5- a]pyri...)
Affinity DataIC50: 23nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709517(N-(4-(4-(4-(3-cyano-4- methoxypyrazolo[1,5- a]pyri...)
Affinity DataIC50: 4nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709517(N-(4-(4-(4-(3-cyano-4- methoxypyrazolo[1,5- a]pyri...)
Affinity DataIC50: 12nMAssay Description:FGFR1 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM709517(N-(4-(4-(4-(3-cyano-4- methoxypyrazolo[1,5- a]pyri...)
Affinity DataIC50: 2nMAssay Description:FGFR2 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709517(N-(4-(4-(4-(3-cyano-4- methoxypyrazolo[1,5- a]pyri...)
Affinity DataIC50: 3nMAssay Description:FGFR3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent