BDBM709305 (Z)-3-fluoro-4-(quinolin-2- ylsulfonyl)but-2-en-1-amine::US12178791, Compound 32

SMILES NC/C=C(F)CS(=O)(=O)c1ccc2ccccc2n1

InChI Key InChIKey=AUTCQVFEJBRLLW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 709305   

TargetProtein-lysine 6-oxidase(Bovine)
Syntara

US Patent
LigandPNGBDBM709305((Z)-3-fluoro-4-(quinolin-2- ylsulfonyl)but-2-en-1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Lysyl oxidase (LOX) is an extracellular copper dependent enzyme which oxidizes peptidyl lysine and hydroxylysine residues in collagen and lysine resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Syntara

US Patent
LigandPNGBDBM709305((Z)-3-fluoro-4-(quinolin-2- ylsulfonyl)but-2-en-1-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Lysyl oxidase (LOX) is an extracellular copper dependent enzyme which oxidizes peptidyl lysine and hydroxylysine residues in collagen and lysine resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Syntara

US Patent
LigandPNGBDBM709305((Z)-3-fluoro-4-(quinolin-2- ylsulfonyl)but-2-en-1-...)
Affinity DataIC50: 3.00E+4nMAssay Description:The specificity of the compounds of this invention was tested by determining their ability to inhibit MAO-B activities in vitro. Recombinant human MA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent