BDBM709101 US12172975, Example 77::tert-butyl N-[(1R,2S)-2-[({2-methoxy-5-[3-(methylcarbam-oyl)-1H-indazol-6-yl]pyridin-3-yl}formamido)methyl]-cyclohexyl]carbamate

SMILES CNC(=O)c1n[nH]c2cc(-c3cnc(OC)c(C(=O)NC[C@@H]4CCCC[C@H]4NC(=O)OC(C)(C)C)c3)ccc12

InChI Key InChIKey=JUMNMLOXJORDJC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 709101   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM709101(tert-butyl N-[(1R,2S)-2-[({2-methoxy-5-[3-(methylc...)
Affinity DataIC50: 3.80nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1 (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent