BDBM709090 6-(5-{[(2-methanesulfonyl-phenyl)methyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carbox-amide::US12172975, Example 66

SMILES CNC(=O)c1n[nH]c2cc(-c3cnc(OC)c(C(=O)NCc4ccccc4S(C)(=O)=O)c3)ccc12

InChI Key InChIKey=HWQNKKOGHLYKKB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 709090   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM709090(6-(5-{[(2-methanesulfonyl-phenyl)methyl]carbamoyl}...)
Affinity DataIC50: 5nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1 (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent