BDBM708954 (S)-2-(7'-(3,5- difluorophenyl)-1'- oxodihydro-1'H,3'H,5'H- spiro [piperidine-4,2'- pyrazolo[1,2-a]pyrazol]-1- yl)-3,5,6- trifluoroisonicotinonitrile::US20240425524, Example 1.51

SMILES N#Cc1c(F)c(F)nc(N2CCC3(CC2)CN2CC[C@@H](c4cc(F)cc(F)c4)N2C3=O)c1F

InChI Key InChIKey=NCUDIVJOPNJBOZ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 708954   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM708954((S)-2-(7'-(3,5- difluorophenyl)-1'- oxodihydro-1'H...)
Affinity DataEC50:  189nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution: top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
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