BDBM708045 2-((3S,6S)-1-(3,4- dichlorobenzoyl)-6- methylpiperidin-3-yl)-5-hydroxy- N-(isoxazol-4-yl)-1-methyl-6-oxo- 1,6-dihydropyrimidine-4- carboxamide::US12172990, Example 84

SMILES C[C@H]1CC[C@H](c2nc(C(=O)Nc3cnoc3)c(O)c(=O)n2C)CN1C(=O)c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=UDRDMIBKRDJJCO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 708045   

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM708045(2-((3S,6S)-1-(3,4- dichlorobenzoyl)-6- methylpiper...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM708045(2-((3S,6S)-1-(3,4- dichlorobenzoyl)-6- methylpiper...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent