BDBM708014 5-hydroxy-N- (isoxazol-4-yl)-2-(1- (4-methoxybenzoyl) piperidin-3-yl)- 1-methyl-6- oxo-1,6- dihydropyrimidine-4- carboxamide::US12172990, Example 47

SMILES COc1ccc(C(=O)N2CCCC(c3nc(C(=O)Nc4cnoc4)c(O)c(=O)n3C)C2)cc1

InChI Key InChIKey=YSEPCJGOVRYWCP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 708014   

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM708014(5-hydroxy-N- (isoxazol-4-yl)-2-(1- (4-methoxybenzo...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM708014(5-hydroxy-N- (isoxazol-4-yl)-2-(1- (4-methoxybenzo...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent