BDBM708010 5-hydroxy-N- (isoxazol-4-yl)-1- methyl-6-oxo-2-(1-(3- phenylpropanoyl) piperidin-3-yl)-1,6- dihydropyrimidine-4- carboxamide::US12172990, Example 43

SMILES Cn1c(C2CCCN(C(=O)CCc3ccccc3)C2)nc(C(=O)Nc2cnoc2)c(O)c1=O

InChI Key InChIKey=YPSGZDHOUWHXIY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 708010   

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM708010(5-hydroxy-N- (isoxazol-4-yl)-1- methyl-6-oxo-2-(1-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM708010(5-hydroxy-N- (isoxazol-4-yl)-1- methyl-6-oxo-2-(1-...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent