BDBM708001 5-hydroxy-N- (isoxazol-4-yl)-1- methyl-2-(3-methyl-5- ((6-methylpyridin-2- yl)amino)phenyl)-6- oxo-1,6- dihydropyrimidine-4- carboxamide::US12172990, Example 34

SMILES Cc1cc(Nc2cccc(C)n2)cc(-c2nc(C(=O)Nc3cnoc3)c(O)c(=O)n2C)c1

InChI Key InChIKey=CPSTWYOSDLICTD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 708001   

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM708001(5-hydroxy-N- (isoxazol-4-yl)-1- methyl-2-(3-methyl...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM708001(5-hydroxy-N- (isoxazol-4-yl)-1- methyl-2-(3-methyl...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent