BDBM707953 6-(6-methoxy d3-5-((1-(2-(trifluoromethoxy)phenyl) ethyl)carbamoyl)pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide, homochiral, unknown enantiomer::US12172975, Example 15

SMILES [2H]C([2H])([2H])Oc1ncc(-c2ccc3c(C(=O)NC)n[nH]c3c2)cc1C(=O)NC(C)c1ccccc1OC(F)(F)F

InChI Key InChIKey=UIPUUQFRKTVEKI-HPRDVNIFSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 707953   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM707953(6-(6-methoxy d3-5-((1-(2-(trifluoromethoxy)phenyl)...)
Affinity DataIC50: 5nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1 (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent