BDBM707898 (1S,2S)-N-[(7S,13S)-(20M)-20-[5-[(9αR)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-2-[(1S)-1-methoxyethyl]-3-pyridyl]-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,30,31-tetrazahexacyclo[23.3.1.12,5.19,13.019,27.021,26]hentriaconta-1 (28),2,5 (31),19,25 ::US20240417410, Example 103

SMILES CO[C@@H](C)c1ncc(N2CCN3CCCC[C@@H]3C2)cc1-c1c2c3cc(cc4c3n1CCC4)-c1csc(n1)C[C@H](NC(=O)[C@H]1C[C@@H]1c1cncnc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2

InChI Key InChIKey=HSSZYURGRIWJPO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 707898   

LigandPNGBDBM707898((1S,2S)-N-[(7S,13S)-(20M)-20-[5-[(9αR)-1,3,4,6,7,8...)
Affinity DataIC50: 6nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
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LigandPNGBDBM707898((1S,2S)-N-[(7S,13S)-(20M)-20-[5-[(9αR)-1,3,4,6,7,8...)
Affinity DataIC50: 7.11E+4nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707898((1S,2S)-N-[(7S,13S)-(20M)-20-[5-[(9αR)-1,3,4,6,7,8...)
Affinity DataIC50: 1.12E+4nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent