BDBM707393 (2S,3R)-1-{5-fluoro-4-[1-(1- methyl-3-azetidinyl)-4-pyrazolyl]- 6-(trifluoromethyl)-2- pyrimidinyl}-2-methyl-3- azetidinol::US20240409530, Compound A27

SMILES C[C@H]1[C@H](O)CN1c1nc(-c2cnn(C3CN(C)C3)c2)c(F)c(C(F)(F)F)n1

InChI Key InChIKey=DIEZUHNAKSKVPT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 707393   

TargetKetohexokinase(Human)
Centennial Therapeutics

US Patent
LigandPNGBDBM707393((2S,3R)-1-{5-fluoro-4-[1-(1- methyl-3-azetidinyl)-...)
Affinity DataIC50: 4.09nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent