BDBM707353 US20240408064, Compound 10086

SMILES O=C(Cc1c[nH]c2cc(F)ccc12)N1CCC(O)CC1

InChI Key InChIKey=JAQXUGUPJRMZTB-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 707353   

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707353(US20240408064, Compound 10086)
Affinity DataKd:  3.18E+3nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707353(US20240408064, Compound 10086)
Affinity DataKd:  1.95E+6nMAssay Description:MST experiments were performed with a Monolith NT.115 Pico (NanoTemper Technologies, Munich, Germany). Fluorescence labeling of GDP-HRasG12V was achi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent