BDBM707324 (R)-2-((2-Amino-7-(2-(1-methylpiperidin-4-yl)pyrimidin-5-yl)pyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol 8::US12162879, Example 8

SMILES CCCC[C@](C)(CO)Nc1nc(N)nc2cc(-c3cnc(C4CCN(C)CC4)nc3)cnc12

InChI Key InChIKey=DTOJPNAFMGNCBS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 707324   

TargetCytochrome P450 3A4(Human)
Jiangsu Hengrui Medicine Co.

US Patent
LigandPNGBDBM707324((R)-2-((2-Amino-7-(2-(1-methylpiperidin-4-yl)pyrim...)
Affinity DataIC50: 3.00E+4nMAssay Description:Table 2: I. Experimental Materials and Instruments1. Phosphate buffer solution (PBS) (Shanghai Basalmedia Technologies Co., Ltd., B320, similarly her...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Jiangsu Hengrui Medicine Co.

US Patent
LigandPNGBDBM707324((R)-2-((2-Amino-7-(2-(1-methylpiperidin-4-yl)pyrim...)
Affinity DataIC50: 3.00E+4nMAssay Description:Table 3: I. Experimental Materials and Instruments1. Phosphate buffer solution (PBS);2. NADPH (Sigma N-1630);3. Human liver microsome (Corning Gentes...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Jiangsu Hengrui Medicine Co.

US Patent
LigandPNGBDBM707324((R)-2-((2-Amino-7-(2-(1-methylpiperidin-4-yl)pyrim...)
Affinity DataIC50: 3.00E+4nMAssay Description:Table 4: I. Experimental Materials and Instruments1. Phosphate buffer solution (PBS);2. NADPH (Sigma N-1630);3. Human liver microsome (Corning Gentes...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent