BDBM707189 N-cyclopropyl-5-(4-((7-ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)piperazin-1-yl)picolinamide ::US20240400586, Compound 4

SMILES CCC1=CC2N=CC(CN3CCN(c4ccc(C(=O)NC5CC5)nc4)CC3)CC2NC1=O

InChI Key InChIKey=GTCQRARQFNUVRK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 707189   

TargetPoly [ADP-ribose] polymerase 1(Human)
Haisco Pharmaceutical Group

US Patent
LigandPNGBDBM707189(N-cyclopropyl-5-(4-((7-ethyl-6-oxo-5,6-dihydro-1,5...)
Affinity DataIC50: 0.670nMAssay Description:Table 1: PARP1 chemical fluorescence detection kit was purchased from BPS Bioscience. The histone solution in the kit was diluted 5× with 1×PBS, and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Haisco Pharmaceutical Group

US Patent
LigandPNGBDBM707189(N-cyclopropyl-5-(4-((7-ethyl-6-oxo-5,6-dihydro-1,5...)
Affinity DataIC50: 27.5nMAssay Description:Table 2: PARP2, PARP5A, PARP5B, PARP6, PARP7, PARP14 and PARP15 chemical fluorescence detection kits were purchased from BPS Bioscience. The histone ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Haisco Pharmaceutical Group

US Patent
LigandPNGBDBM707189(N-cyclopropyl-5-(4-((7-ethyl-6-oxo-5,6-dihydro-1,5...)
Affinity DataIC50: 6.08E+3nMAssay Description:Table 2: PARP2, PARP5A, PARP5B, PARP6, PARP7, PARP14 and PARP15 chemical fluorescence detection kits were purchased from BPS Bioscience. The histone ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Haisco Pharmaceutical Group

US Patent
LigandPNGBDBM707189(N-cyclopropyl-5-(4-((7-ethyl-6-oxo-5,6-dihydro-1,5...)
Affinity DataIC50: 576nMAssay Description:Table 2: PARP2, PARP5A, PARP5B, PARP6, PARP7, PARP14 and PARP15 chemical fluorescence detection kits were purchased from BPS Bioscience. The histone ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP6(Human)
Haisco Pharmaceutical Group

US Patent
LigandPNGBDBM707189(N-cyclopropyl-5-(4-((7-ethyl-6-oxo-5,6-dihydro-1,5...)
Affinity DataIC50: 6.86E+3nMAssay Description:Table 2: PARP2, PARP5A, PARP5B, PARP6, PARP7, PARP14 and PARP15 chemical fluorescence detection kits were purchased from BPS Bioscience. The histone ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Haisco Pharmaceutical Group

US Patent
LigandPNGBDBM707189(N-cyclopropyl-5-(4-((7-ethyl-6-oxo-5,6-dihydro-1,5...)
Affinity DataIC50: 5.36E+3nMAssay Description:Table 2: PARP2, PARP5A, PARP5B, PARP6, PARP7, PARP14 and PARP15 chemical fluorescence detection kits were purchased from BPS Bioscience. The histone ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Haisco Pharmaceutical Group

US Patent
LigandPNGBDBM707189(N-cyclopropyl-5-(4-((7-ethyl-6-oxo-5,6-dihydro-1,5...)
Affinity DataIC50: 7.06E+3nMAssay Description:Table 2: PARP2, PARP5A, PARP5B, PARP6, PARP7, PARP14 and PARP15 chemical fluorescence detection kits were purchased from BPS Bioscience. The histone ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP15(Human)
Haisco Pharmaceutical Group

US Patent
LigandPNGBDBM707189(N-cyclopropyl-5-(4-((7-ethyl-6-oxo-5,6-dihydro-1,5...)
Affinity DataIC50: 4.30E+3nMAssay Description:Table 2: PARP2, PARP5A, PARP5B, PARP6, PARP7, PARP14 and PARP15 chemical fluorescence detection kits were purchased from BPS Bioscience. The histone ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent