BDBM706966 US20240400537, Example EX-I-27::cis-3-(6-(2,2- difluoroethoxy)-4,5- dimethylpyridazin-3-yl)- 8-(3,5-difluorophenyl)-8- (dimethylamino)-1,3- diazaspiro [4.5]decan-2- one

SMILES Cc1c(OCC(F)F)nnc(N2C[C@]3(CC[C@](c4cc(F)cc(F)c4)(N(C)C)CC3)NC2=O)c1C

InChI Key InChIKey=LPDXCIONYOYNDD-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 706966   

TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM706966(cis-3-(6-(2,2- difluoroethoxy)-4,5- dimethylpyrida...)
Affinity DataKi:  0.700nMAssay Description:The human nociceptin (hNOP) receptor binding assay was performed as an filtration-based radio agonist binding assay. Cell membrane homogenates of tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM706966(cis-3-(6-(2,2- difluoroethoxy)-4,5- dimethylpyrida...)
Affinity DataKi:  737nMAssay Description:The human μ-opioid (hMOP) receptor binding assay was performed as an filtration-based radio agonist binding assay. Cell membranes of transfected CHO ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM706966(cis-3-(6-(2,2- difluoroethoxy)-4,5- dimethylpyrida...)
Affinity DataKi:  1.14E+3nMAssay Description:The human δ2-opioid (hDOP) receptor binding assay was performed as an filtration-based radio agonist binding assay. Cell membrane homogenates of tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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TargetKappa-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM706966(cis-3-(6-(2,2- difluoroethoxy)-4,5- dimethylpyrida...)
Affinity DataKi:  1.67E+3nMAssay Description:The human κ-opioid (hKOP) receptor assay was performed as an filtration-based radio agonist binding assay. Cell membranes of transfected CHO cells (1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent