BDBM706947 US20240400537, Example EX-I-10::cis-8-(3,5- difluorophenyl)-8- (dimethylamino)-3-(3- methyl-5- (methylsulfonyl)pyridin- 2-yl)-1,3- diazaspiro[4.5]decan-2- one

SMILES Cc1cc(S(C)(=O)=O)cnc1N1C[C@]2(CC[C@](c3cc(F)cc(F)c3)(N(C)C)CC2)NC1=O

InChI Key InChIKey=ZSTUUHTVFCLMFC-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 706947   

TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM706947(cis-8-(3,5- difluorophenyl)-8- (dimethylamino)-3-(...)
Affinity DataKi:  2.70nMAssay Description:The human nociceptin (hNOP) receptor binding assay was performed as an filtration-based radio agonist binding assay. Cell membrane homogenates of tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM706947(cis-8-(3,5- difluorophenyl)-8- (dimethylamino)-3-(...)
Affinity DataKi:  784nMAssay Description:The human μ-opioid (hMOP) receptor binding assay was performed as an filtration-based radio agonist binding assay. Cell membranes of transfected CHO ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM706947(cis-8-(3,5- difluorophenyl)-8- (dimethylamino)-3-(...)
Affinity DataKi: >1.00E+3nMAssay Description:The human κ-opioid (hKOP) receptor assay was performed as an filtration-based radio agonist binding assay. Cell membranes of transfected CHO cells (1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM706947(cis-8-(3,5- difluorophenyl)-8- (dimethylamino)-3-(...)
Affinity DataKi:  2.18E+3nMAssay Description:The human δ2-opioid (hDOP) receptor binding assay was performed as an filtration-based radio agonist binding assay. Cell membrane homogenates of tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent