BDBM706753 US20240398759, Compound 001::US20250059156, Compound Mesembrine::mesembrine

SMILES COc1ccc([C@@]23CCC(=O)C[C@@H]2N(C)CC3)cc1OC

InChI Key InChIKey=DAHIQPJTGIHDGO-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 706753   

TargetIsoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1)(Human)
Sensorium Therapeutics

US Patent
LigandPNGBDBM706753(mesembrine | US20240398759, Compound 001 | US20250...)
Affinity DataIC50: 4.30E+3nMAssay Description:Step 1:1) Dilute 20 μM FAM-Cyclic-3′, 5′-AMP stock 100-fold with PDE buffer to make a 200 nM solution.2) Add 25 μl of FAM-Cyclic-3′,5′-AMP (200 nM) t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM706753(mesembrine | US20240398759, Compound 001 | US20250...)
Affinity DataIC50: 3.20E+3nMAssay Description:Step 1:1) Dilute 20 μM FAM-Cyclic-3′, 5′-AMP stock 100-fold with PDE buffer to make a 200 nM solution.2) Add 25 μl of FAM-Cyclic-3′,5′-AMP (200 nM) t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Sensorium Therapeutics

US Patent
LigandPNGBDBM706753(mesembrine | US20240398759, Compound 001 | US20250...)
Affinity DataIC50: 1.50E+4nMAssay Description:Step 1:1) Dilute 20 μM FAM-Cyclic-3′, 5′-AMP stock 100-fold with PDE buffer to make a 200 nM solution.2) Add 25 μl of FAM-Cyclic-3′,5′-AMP (200 nM) t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetIsoform 2 of 3',5'-cyclic-AMP phosphodiesterase 4D(Homo sapiens (Human))
Sensorium Therapeutics

US Patent
LigandPNGBDBM706753(mesembrine | US20240398759, Compound 001 | US20250...)
Affinity DataIC50: 2.70E+3nMAssay Description:Step 1:1) Dilute 20 μM FAM-Cyclic-3′, 5′-AMP stock 100-fold with PDE buffer to make a 200 nM solution.2) Add 25 μl of FAM-Cyclic-3′,5′-AMP (200 nM) t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sensorium Therapeutics

US Patent
LigandPNGBDBM706753(mesembrine | US20240398759, Compound 001 | US20250...)
Affinity DataIC50: 7.80E+3nMAssay Description:1) Dilute 20 μM FAM-Cyclic-3′, 5′-AMP stock 100-fold with PDE buffer to make a 200 nM solution. Make only sufficient quantity needed for the assay; s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
Sensorium Therapeutics

US Patent
LigandPNGBDBM706753(mesembrine | US20240398759, Compound 001 | US20250...)
Affinity DataKi:  1.40nMAssay Description:SERT inhibition was measured using a Neruotransmitter Transportation Fluorescence assay. Briefly, stable 5HHH cells were prepared in a 384 microwell ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
Go to US Patent