BDBM705365 US12145945, Example 26

SMILES COc1cnc(Cl)cc1c2cc(C)ncc2C(=O)Nc5nc4cnc(N3CC[C@H](O)C3)nc4s5

InChI Key InChIKey=AEZHRWRQIBMFAF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 705365   

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM705365(US12145945, Example 26)
Affinity DataIC50: 100nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Polθ protein (P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/8/2025
Entry Details
Go to US Patent