BDBM705293 (E)-3-(3-(3,5- bis(trifluoromethyl)phenyl)-1H-1,2,4- triazol-1-yl)-1-(3,3-difluoroazetidin-1- yl)prop-2-en-1-one::US20240376114, Compound 4

SMILES O=C(/C=C/n2cnc(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)n2)N3CC(F)(F)C3

InChI Key InChIKey=JCHAWRDHMUSLMM-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 705293   

TargetProtein Rev(Human immunodeficiency virus type 1)
Karyopharm Therapeutics

US Patent
LigandPNGBDBM705293((E)-3-(3-(3,5- bis(trifluoromethyl)phenyl)-1H-1,2,...)
Affinity DataIC50: 1.00E+3nMAssay Description:The ability of exemplary compounds of the invention to inhibit CRM1-mediated nuclear export was assessed in a RevGFP assay. Rev is a protein from hum...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
3/20/2025
Entry Details
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