BDBM705149 4-(6-((R)-4-((3,3-dimethy]-2,3- dihydro-[1,4]dioxino[2,3-b] pyridin-8-yl)methyl)-2-(2- isopropylphenyl)piperazin-1-yl)-2- azaspiro[3.3]heptan-2-yl)-2-((3- fluoro-1H-pyrrolo[2,3-b]pyridin-5- yl)oxy)-N-((4-((((1r,4r)-4-hydroxy- 4-methylcyclohexyl)methyl) amino)-3-nitrophenyl)sulfonyl) benzamide::US20240376097, Example 317
SMILES CC(C)c1ccccc1[C@@H]1CN(Cc2ccnc3c2OCC(C)(C)O3)CCN1C1CC2(C1)CN(c1ccc(C(=O)NS(=O)(=O)c3ccc(NC[C@H]4CC[C@](C)(O)CC4)c([N+](=O)[O-])c3)c(Oc3cnc4[nH]cc(F)c4c3)c1)C2
InChI Key InChIKey=CBBLHWMFAGEHGG-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 705149
Affinity DataIC50: 0.0330nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Affinity DataIC50: 0.120nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0570nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2D 103Y protein with its ligand in an assay based on time-resolved fluorescence r...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0330nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair