BDBM705146 2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(6-((R)-4-((2,2-dimethyl- 2,3-dihydro-[1,4]dioxino[2,3-b] pyridin-8-yl)methyl)-2-(2- isopropylphenyl)piperazin-1-yl)-2- azaspiro[3.3]heptan-2-yl)-N-((4- ((((1r,4r)-4-hydroxy-4- methylcyclohexyl)methyl)amino)- 3-nitrophenyl)sulfonyl)benzamide::US20240376097, Example 314

SMILES CC(C)c1ccccc1[C@@H]1CN(Cc2ccnc3c2OC(C)(C)CO3)CCN1C1CC2(C1)CN(c1ccc(C(=O)NS(=O)(=O)c3ccc(NC[C@H]4CC[C@](C)(O)CC4)c([N+](=O)[O-])c3)c(Oc3cnc4[nH]ccc4c3)c1)C2

InChI Key InChIKey=WXWAZXYWIRSJCG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 705146   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM705146(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(6-((R)-...)
Affinity DataIC50: 0.0320nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705146(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(6-((R)-...)
Affinity DataIC50: 0.130nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent