BDBM705099 2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-((R)-4-(3,4-bis(methoxy- d3)benzyl)-2-(2-isopropylphenyl) piperazin-1-yl)-7-azaspiro[3.5] nonan-7-yl)-N-((4-((((1r,4r)-4- hydroxy-4-methylcyclohexyl) methyl)amino)-3-nitrophenyl) sulfonyl)benzamide::US20240376097, Example 253

SMILES [2H]C([2H])([2H])Oc1ccc(CN2CCN(C3CC4(CCN(c5ccc(C(=O)NS(=O)(=O)c6ccc(NC[C@H]7CC[C@](C)(O)CC7)c([N+](=O)[O-])c6)c(Oc6cnc7[nH]ccc7c6)c5)CC4)C3)[C@H](c3ccccc3C(C)C)C2)cc1OC([2H])([2H])[2H]

InChI Key InChIKey=FSEQKLMWHOZIFV-RKAHMFOGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 705099   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM705099(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-((R)-...)
Affinity DataIC50: 0.0270nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705099(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-((R)-...)
Affinity DataIC50: 0.0890nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent