BDBM705093 2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(6-((R)-4-(3,4-bis(methoxy- d3)benzyl)-2-(2-isopropylphenyl) piperazin-1-yl)-2-azaspiro[3.3] heptan-2-yl)-N-((4-((((1r,4r)-4- hydroxy-4-methylcyclohexyl) methyl)amino)-3-nitrophenyl) sulfonyl)benzamide::US20240376097, Example 243
SMILES [2H]C([2H])([2H])Oc1ccc(CN2CCN(C3CC4(C3)CN(c3ccc(C(=O)NS(=O)(=O)c5ccc(NC[C@H]6CC[C@](C)(O)CC6)c([N+](=O)[O-])c5)c(Oc5cnc6[nH]ccc6c5)c3)C4)[C@H](c3ccccc3C(C)C)C2)cc1OC([2H])([2H])[2H]
InChI Key InChIKey=MKUCHAURDRGRGY-RKAHMFOGSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 705093
Affinity DataIC50: 0.0400nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0860nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0410nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2D 103Y protein with its ligand in an assay based on time-resolved fluorescence r...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0410nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair