BDBM705066 4-(2-((R)-4-(3,4-bis(methoxy-d3) benzyl)-2-(2-isopropylphenyl) piperazin-1-yl)-7-azaspiro[3.5] nonan-7-yl)-2-((3-fluoro-1H- pyrrolo[2,3-b]pyridin-5-yl)oxy)- N-((4-((((1r,4r)-4-hydroxy-4- methylcyclohexyl)methyl)amino)- 3-nitrophenyl)sulfonyl)benzamide::US20240376097, Example 198
SMILES [2H]C([2H])([2H])Oc1ccc(CN2CCN(C3CC4(CCN(c5ccc(C(=O)NS(=O)(=O)c6ccc(NC[C@H]7CC[C@](C)(O)CC7)c([N+](=O)[O-])c6)c(Oc6cnc7[nH]cc(F)c7c6)c5)CC4)C3)[C@H](c3ccccc3C(C)C)C2)cc1OC([2H])([2H])[2H]
InChI Key InChIKey=DYMOPRIRAKDDSB-RKAHMFOGSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 705066
Affinity DataIC50: 0.0720nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2D 103Y protein with its ligand in an assay based on time-resolved fluorescence r...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0720nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair