BDBM705065 4-(6-((R)-4-(3,4-bis(methoxy-d3) benzyl)-2-(2-isopropylphenyl) piperazin-1-yl)-2-azaspiro[3.3] heptan-2-yl)-2-((3-fluoro-1H- pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((1r,4r)-4-hydroxy-4- methylcyclohexyl)methyl)amino)- 3-nitrophenyl)sulfonyl)benzamide::US20240376097, Example 197
SMILES [2H]C([2H])([2H])Oc1ccc(CN2CCN(C3CC4(C3)CN(c3ccc(C(=O)NS(=O)(=O)c5ccc(NC[C@H]6CC[C@](C)(O)CC6)c([N+](=O)[O-])c5)c(Oc5cnc6[nH]cc(F)c6c5)c3)C4)[C@H](c3ccccc3C(C)C)C2)cc1OC([2H])([2H])[2H]
InChI Key InChIKey=XCGVKZJSEHSYCX-RKAHMFOGSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 705065
Affinity DataIC50: 0.0760nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0890nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2D 103Y protein with its ligand in an assay based on time-resolved fluorescence r...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0760nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair