BDBM705063 2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-(4-(3,4- dimethoxyphenyl)methyl-d2)-2-(2- isopropylphenyl)piperazin-1-yl)-7- azaspiro[3.5]nonan-7-yl)-N-((4- ((((1r,4r)-4-hydroxy-4- methylcyclohexyl)methyl)amino)- 3-nitrophenyl)sulfonyl)benzamide::US20240376097, Example 193

SMILES [2H]C([2H])(c1ccc(OC)c(OC)c1)N1CCN(C2CC3(CCN(c4ccc(C(=O)NS(=O)(=O)c5ccc(NC[C@H]6CC[C@](C)(O)CC6)c([N+](=O)[O-])c5)c(Oc5cnc6[nH]ccc6c5)c4)CC3)C2)C(c2ccccc2C(C)C)C1

InChI Key InChIKey=FSEQKLMWHOZIFV-YXXKQLJWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 705063   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM705063(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-(4-(3...)
Affinity DataIC50: 0.0680nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705063(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-(4-(3...)
Affinity DataIC50: 0.230nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent