BDBM705062 (R)-4-(2-(4-(3,4-dimethoxybenzyl)- 2-(2-isopropylphenyl)piperazin-1- yl)-7-azaspiro[3.5]nonan-7-yl)-2- ((3-fluoro-1H-pyrolo[2,3-b] pyridin-5-yl)oxy)-N-((3-nitro-4- (((tetrahydro-2H-pyran-4-yl) methyl)amino)phenyl)sulfonyl) benzamide::US20240376097, Example 191

SMILES COc1ccc(CN2CCN(C3CC4(CCN(c5ccc(C(=O)NS(=O)(=O)c6ccc(NCC7CCOCC7)c([N+](=O)[O-])c6)c(Oc6cnc7[nH]cc(F)c7c6)c5)CC4)C3)[C@H](c3ccccc3C(C)C)C2)cc1OC

InChI Key InChIKey=LFCNIKJHBGFTBI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 705062   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM705062((R)-4-(2-(4-(3,4-dimethoxybenzyl)- 2-(2-isopropylp...)
Affinity DataIC50: 0.0610nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705062((R)-4-(2-(4-(3,4-dimethoxybenzyl)- 2-(2-isopropylp...)
Affinity DataIC50: 0.200nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent