BDBM705057 (R)-2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-4-(6-(2-(2- isopropylphenyl)-4-(4- methoxybenzyl)piperazin-1-yl)-2- azaspiro[3.3]heptan-2-yl)-N-((3- nitro-4-(((tetrahydro-2H-pyran-4- yl)methyl)amino)phenyl)sulfonyl) benzamide::US20240376097, Example 183

SMILES COc1ccc(CN2CCN(C3CC4(C3)CN(c3ccc(C(=O)NS(=O)(=O)c5ccc(NCC6CCOCC6)c([N+](=O)[O-])c5)c(Oc5cnc6[nH]cc(F)c6c5)c3)C4)[C@H](c3ccccc3C(C)C)C2)cc1

InChI Key InChIKey=ULLZHASVEMYFFD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 705057   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM705057((R)-2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)ox...)
Affinity DataIC50: 0.0960nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM705057((R)-2-((3-fluoro-1H-pyrrolo[2,3-b] pyridin-5-yl)ox...)
Affinity DataIC50: 0.180nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent