BDBM704929 US20240376097, Example 19a::synthesized from intermediate 19-1a in Method A”)

SMILES COc1ccc(CN2CCN(C3CC4(CCN(c5ccc(C(=O)NS(=O)(=O)c6ccc(NC[C@H]7CC[C@](C)(O)CC7)c([N+](=O)[O-])c6)c(Oc6cnc7[nH]ccc7c6)c5)CC4)C3)[C@@H](c3ccccc3C(C)C)C2)cc1

InChI Key InChIKey=DJVYDMNBLDYQCK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 704929   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM704929(synthesized from intermediate 19-1a in Method A”) ...)
Affinity DataIC50: 0.0570nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM704929(synthesized from intermediate 19-1a in Method A”) ...)
Affinity DataIC50: 0.0570nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [D103Y](Human)
Beigene

US Patent
LigandPNGBDBM704929(synthesized from intermediate 19-1a in Method A”) ...)
Affinity DataIC50: 0.150nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2D 103Y protein with its ligand in an assay based on time-resolved fluorescence r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704929(synthesized from intermediate 19-1a in Method A”) ...)
Affinity DataIC50: 0.180nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent