BDBM704698 US20240376080, Compound 2R

SMILES [2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)[C@@H]2CC23CC3)cc1Nc1nccc(-c2ncn(C)n2)c1OC

InChI Key InChIKey=BFBCSHXBVZNRRU-FIBGUPNXSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 704698   

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Zhejiang Wenda Pharmaceutical Technology

US Patent
LigandPNGBDBM704698(US20240376080, Compound 2R)
Affinity DataIC50: 9.95E+3nMAssay Description:1. Experimental Method1.1. Pseudokinase (JH2) Experimental Operation was as Follows:1.1.1. Dissolve the compound with DMSO to a storage concentration...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Zhejiang Wenda Pharmaceutical Technology

US Patent
LigandPNGBDBM704698(US20240376080, Compound 2R)
Affinity DataIC50: 0.200nMAssay Description:1. Experimental Method1.1. Pseudokinase (JH2) Experimental Operation was as Follows:1.1.1. Dissolve the compound with DMSO to a storage concentration...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Zhejiang Wenda Pharmaceutical Technology

US Patent
LigandPNGBDBM704698(US20240376080, Compound 2R)
Affinity DataIC50: 698nMAssay Description:1. Experimental Method1.1. Pseudokinase (JH2) Experimental Operation was as Follows:1.1.1. Dissolve the compound with DMSO to a storage concentration...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [583-855](Human)
Zhejiang Wenda Pharmaceutical Technology

US Patent
LigandPNGBDBM704698(US20240376080, Compound 2R)
Affinity DataIC50: 1.70nMAssay Description:1. Experimental Method1.1. Pseudokinase (JH2) Experimental Operation was as Follows:1.1.1. Dissolve the compound with DMSO to a storage concentration...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Zhejiang Wenda Pharmaceutical Technology

US Patent
LigandPNGBDBM704698(US20240376080, Compound 2R)
Affinity DataIC50: 9.95E+3nMAssay Description:1. Experimental Method1.1. Pseudokinase (JH2) Experimental Operation was as Follows:1.1.1. Dissolve the compound with DMSO to a storage concentration...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [811-1124](Human)
Zhejiang Wenda Pharmaceutical Technology

US Patent
LigandPNGBDBM704698(US20240376080, Compound 2R)
Affinity DataIC50: 3.68E+3nMAssay Description:1. Experimental Method1.1. Pseudokinase (JH2) Experimental Operation was as Follows:1.1.1. Dissolve the compound with DMSO to a storage concentration...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent