BDBM704209 US12139488, Example 96

SMILES CN(C)C(=O)c5cn(c4ccc3ncnc(Nc2c(F)ccc(NS(=O)(=O)c1ccccc1Cl)c2F)c3n4)c6cccc(N)c56

InChI Key InChIKey=NGLFDDLVPKUZRH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 704209   

TargetSerine/threonine-protein kinase B-raf(Human)
Université

US Patent
LigandPNGBDBM704209(US12139488, Example 96)
Affinity DataIC50: 1nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Université

US Patent
LigandPNGBDBM704209(US12139488, Example 96)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent