BDBM704187 Example 524 (Iron Metal as Reducing Agent for Step 2)::US12139488, Example 524

SMILES CC7(O)CCN(c1cccc2c1ccn2c6ccc5ncnc(Nc4c(F)ccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c4F)c5n6)CC7

InChI Key InChIKey=YAMDBYWVYODFIX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 704187   

TargetSerine/threonine-protein kinase A-Raf(Human)
Université

US Patent
LigandPNGBDBM704187(Example 524 (Iron Metal as Reducing Agent for Step...)
Affinity DataIC50: 5.5nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Université

US Patent
LigandPNGBDBM704187(Example 524 (Iron Metal as Reducing Agent for Step...)
Affinity DataIC50: 5.5nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Université

US Patent
LigandPNGBDBM704187(Example 524 (Iron Metal as Reducing Agent for Step...)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent