BDBM704075 N-(3-(difluoromethyl)-1-((1R,4R)-4-(((2-(1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)piperidin-4-yl)ethyl)(methyl)amino)methyl)cyclohexyl)-1H-pyrazol-4-yl)-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::US20240368194, Example 39

SMILES COc1ccc(C(=O)N2CCC(CCN(C)C[C@H]3CC[C@H](n4cc(NC(=O)c5cnn6ccc(N7CC8(COC8)C7)nc56)c(C(F)F)n4)CC3)CC2)cc1N1CCC(=O)NC1=O

InChI Key InChIKey=AYRPJQYCULQHAB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 704075   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Leadingtac Pharmaceutical

US Patent
LigandPNGBDBM704075(N-(3-(difluoromethyl)-1-((1R,4R)-4-(((2-(1-(3-(2,4...)
Affinity DataIC50: 17nMAssay Description:The KinEASE-STK SI serine/threonine kinase kit (Cisbio) was used to test the inhibitory effect of the compounds on the IRAK4 kinase activity, and the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent