BDBM704071 N-(3-(difluoromethyl)-1-((1R,4S)-4-(((2-(1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)piperidin-4-yl)ethyl)(methyl)amino)methyl)cyclohexyl)-1H-pyrazol-4-yl)-5-((S)-3-hydroxypiperidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::US20240368194, Example 35

SMILES COc1ccc(C(=O)N2CCC(CCN(C)C[C@H]3CC[C@H](n4cc(NC(=O)c5cnn6ccc(N7CCC[C@H](O)C7)nc56)c(C(F)F)n4)CC3)CC2)cc1N1CCC(=O)NC1=O

InChI Key InChIKey=DQUWFULMSOMZFP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 704071   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Leadingtac Pharmaceutical

US Patent
LigandPNGBDBM704071(N-(3-(difluoromethyl)-1-((1R,4S)-4-(((2-(1-(3-(2,4...)
Affinity DataIC50: 3.36nMAssay Description:The KinEASE-STK SI serine/threonine kinase kit (Cisbio) was used to test the inhibitory effect of the compounds on the IRAK4 kinase activity, and the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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