BDBM704058 N-(2-((1S,4S)-4-((2-(1-(4-chloro-3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)piperidin-4-yl)ethoxy)methyl)-4-methoxycyclohexyl)-6-methoxy-2H-indol-5-yl)-6-(trifluoromethyl)pyridineamine::US20240368194, Example 22

SMILES COc1cc2nn([C@H]3CC[C@@](COCCC4CCN(C(=O)c5ccc(Cl)c(N6CCC(=O)NC6=O)c5)CC4)(OC)CC3)cc2cc1NC(=O)c1cccc(C(F)(F)F)n1

InChI Key InChIKey=NZYGSIURQAQEQU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 704058   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Leadingtac Pharmaceutical

US Patent
LigandPNGBDBM704058(N-(2-((1S,4S)-4-((2-(1-(4-chloro-3-(2,4-dioxotetra...)
Affinity DataIC50: 9.29nMAssay Description:The KinEASE-STK SI serine/threonine kinase kit (Cisbio) was used to test the inhibitory effect of the compounds on the IRAK4 kinase activity, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
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