BDBM703928 N-[(5-amino-6-bromo-1H-pyrrolo[3,2-b]pyridin-2- yl)methyl]pyrimidine-4-carboxamide. LCMS [ESI, M + 1]+ = 346.9. 1H NMR (400 MHz, MeOD) $#948; = 9.30 (d, J = 1.2 Hz, 1H), 9.05 (d, J = 5.2 Hz, 1H), 8.32 (s, 1H), 8.12 (dd, J = 1.2, 5.2 Hz, 1H), 6.43 (s, 1H), 4.81-4.77 (m, 2H).::US20240368153, Example 8-2

SMILES Nc1nc2cc(CNC(=O)c3ccncn3)[nH]c2cc1Br

InChI Key InChIKey=YKTLILLSZWVEMX-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 703928   

LigandPNGBDBM703928(N-[(5-amino-6-bromo-1H-pyrrolo[3,2-b]pyridin-2- yl...)
Affinity DataIC50: 13nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703928(N-[(5-amino-6-bromo-1H-pyrrolo[3,2-b]pyridin-2- yl...)
Affinity DataKd:  9nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703928(N-[(5-amino-6-bromo-1H-pyrrolo[3,2-b]pyridin-2- yl...)
Affinity DataKd:  137nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703928(N-[(5-amino-6-bromo-1H-pyrrolo[3,2-b]pyridin-2- yl...)
Affinity DataIC50: 362nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703928(N-[(5-amino-6-bromo-1H-pyrrolo[3,2-b]pyridin-2- yl...)
Affinity DataIC50: 5.79E+3nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent