BDBM703927 N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl]benzamide. LCMS [M + 1]+ = 293.2. 1H NMR (400 MHz, CD3OD- d4) $#948; = 8.82 (d, J = 2.0 Hz, 1H), 7.98 (br d, J = 2.0 Hz, 1H), 7.94-7.83 (m, 2H), 7.61-7.55 (m, 1H), 7.53- 7.46 (m, 2H), 7.12 (s, 1H), 4.79 (s, 2H), 2.75 (s, 3H).::US20240368153, Example 8-1

SMILES Nc1nc2cc(CNC(=O)c3ccccc3)[nH]c2cc1Br

InChI Key InChIKey=PFJAROFBNFXXIE-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 703927   

LigandPNGBDBM703927(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 9nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703927(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataKd:  5nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703927(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataKd:  33nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703927(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 419nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703927(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 4.29E+3nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent