BDBM703922 N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl]-6-hydroxy-pyrimidine-4- carboxamide. LCMS [M + 1]+ = 311.1. 1H NMR (400 MHz, CD3OD) $#948; = 8.81 (d, J = 1.6 Hz, 1H), 8.32 (s, 1H), 7.99 (d, J = 1.6 Hz, 1H), 7.13 (d, J = 1.2 Hz, 1H), 7.10 (s, 1H), 4.78 (s, 2H), 2.75 (d, J = 1.2 Hz, 3H).::US20240368153, Example 7-3

SMILES Cc1cc(N)nc2cc(CNC(=O)c3cc(O)ncn3)cnc12

InChI Key InChIKey=VILAVLZSCXAUJY-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 703922   

LigandPNGBDBM703922(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 1.06E+3nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703922(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataKd:  682nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703922(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataKd:  1.25E+4nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703922(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 6.00E+4nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703922(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent