BDBM703915 6-(2-fluorophenyl)-4-methyl-1,5-naphthyridin-2- amine. LCMS [M + 1] = 254.3. 1H NMR (400 MHz, MeOD) $#948; = 8.10 (dt, J = 1.8, 8.0 Hz, 1H), 7.97- 7.92 (m, 1H), 7.90-7.85 (m, 1H), 7.49-7.40 (m, 1H), 7.34-7.28 (t, J = 7.6, 1H), 7.26-7.19 (m, 1H), 6.95 (d, J = 1.2 Hz, 1H), 2.70 (d, J = 0.8 Hz, 3H).::US20240368153, Example 4-7

SMILES Cc1cc(N)nc2ccc(-c3ccccc3F)nc12

InChI Key InChIKey=IXLWCMCAMKOUDZ-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 703915   

LigandPNGBDBM703915(6-(2-fluorophenyl)-4-methyl-1,5-naphthyridin-2- am...)
Affinity DataIC50: 1.01E+4nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703915(6-(2-fluorophenyl)-4-methyl-1,5-naphthyridin-2- am...)
Affinity DataKd:  3.20E+4nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703915(6-(2-fluorophenyl)-4-methyl-1,5-naphthyridin-2- am...)
Affinity DataKd:  8.14E+4nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703915(6-(2-fluorophenyl)-4-methyl-1,5-naphthyridin-2- am...)
Affinity DataIC50: 3.00E+5nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703915(6-(2-fluorophenyl)-4-methyl-1,5-naphthyridin-2- am...)
Affinity DataIC50: 3.00E+5nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent