BDBM703907 4-methyl-7-(3-pyridyloxy)-1,5-paphthyridin-2- amine. LCMS [M + 1]: 253.2. 1H NMR (400 MHz, CDCl3) $#948; = 8.56 (d, J = 2.8 Hz, 1H), 8.53 (d, J = 2.8 Hz, 1H), 8.49 (dd, J = 4.4, 1.2 Hz, 1H), 7.46-7.43 (m, 1H), 7.36-7.32 (m, 1H), 7.31 (d, J = 2.4 Hz, 1H), 6.73 (d, J = 1.2 Hz, 1H), 4.78 (br, s, 2H), 2.70 (d, J = 0.8 Hz, 3H).::US20240368153, Example 3-7

SMILES Cc1cc(N)nc2cc(Oc3cccnc3)cnc12

InChI Key InChIKey=QTYFKFWMWXABCU-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 703907   

LigandPNGBDBM703907(4-methyl-7-(3-pyridyloxy)-1,5-paphthyridin-2- amin...)
Affinity DataIC50: 546nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
3/14/2025
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LigandPNGBDBM703907(4-methyl-7-(3-pyridyloxy)-1,5-paphthyridin-2- amin...)
Affinity DataKd:  2.46E+3nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703907(4-methyl-7-(3-pyridyloxy)-1,5-paphthyridin-2- amin...)
Affinity DataIC50: 2.61E+4nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703907(4-methyl-7-(3-pyridyloxy)-1,5-paphthyridin-2- amin...)
Affinity DataIC50: 3.51E+5nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent