BDBM703898 4-methyl-7-(3-pyridylmethyl)-1,5-naphthyridin-2- amine. LCMS [M + 1]: 251.3. 1H NMR (400 MHz, MeOD) $#948; = 8.52 (d, J = 2.0 Hz, 1H), 8.45 (d, J = 2.4 Hz, 1H), 8.42 (dd, J = 1.6, 4.8 Hz, 1H), 7.76 (d, J = 8.0 Hz, 1H), 7.64 (d, J = 2.0 Hz, 1H), 7.40 (dd, J = 4.8, 8.0 Hz, 1H), 6.87 (d, J = 0.8 Hz, 1H), 4.20 (s, 2H), 2.60 (s, 3H).::US20240368153, Example 2-7

SMILES Cc1cc(N)nc2cc(Cc3cccnc3)cnc12

InChI Key InChIKey=BEZQIZQUEVITMZ-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 703898   

LigandPNGBDBM703898(4-methyl-7-(3-pyridylmethyl)-1,5-naphthyridin-2- a...)
Affinity DataIC50: 581nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703898(4-methyl-7-(3-pyridylmethyl)-1,5-naphthyridin-2- a...)
Affinity DataKd:  232nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703898(4-methyl-7-(3-pyridylmethyl)-1,5-naphthyridin-2- a...)
Affinity DataKd:  1.22E+3nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent