BDBM703895 2-((6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl)benzonitrile. LCMS [M + 1]: 275.2. 1H NMR (400 MHz, MeOD-d4) $#948; = 8.51 (d, J = 2.0 Hz, 1H), 7.77 (d, J = 7.6 Hz, 1H), 7.71-7.63 (m, 2H), 7.56 (d, J = 7.8 Hz, 1H), 7.49-7.42 (m, 1H), 6.90 (d, J = 0.8 Hz, 1H), 4.40 (s, 2H), 2.62 (d, J = 1.2 Hz, 3H).::US20240368153, Example 2-4

SMILES Cc1cc(N)nc2cc(Cc3ccccc3C#N)cnc12

InChI Key InChIKey=KIWFDUSKXXGDDB-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 703895   

LigandPNGBDBM703895(2-((6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 992nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703895(2-((6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataKd:  874nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703895(2-((6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataKd:  3.09E+3nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703895(2-((6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 3.00E+5nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703895(2-((6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 3.00E+5nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent