BDBM703894 7-(2-chlorobenzyl)-4-methyl-1,5-naphthyridin-2- amine. LCMS [M + 1]: 284.2. 1H NMR (400 MHz, CD3OD) $#948; = 8.47 (d, J = 2.0 Hz, 1H), 7.63-7.56 (m, 1H), 7.43 (ddd, J = 1.6, 7.6, 12.0 Hz, 2H), 7.31 (dquin, J = 1.6, 7.6 Hz, 2H), 6.88 (d, J = 1.2 Hz, 1H), 4.30 (s, 2H), 2.62 (d, J = 1.0 Hz, 3H).::US20240368153, Example 2-3

SMILES Cc1cc(N)nc2cc(Cc3ccccc3Cl)cnc12

InChI Key InChIKey=AVIXZBQYRSVXTA-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 703894   

LigandPNGBDBM703894(7-(2-chlorobenzyl)-4-methyl-1,5-naphthyridin-2- am...)
Affinity DataIC50: 1.31E+3nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703894(7-(2-chlorobenzyl)-4-methyl-1,5-naphthyridin-2- am...)
Affinity DataKd:  4.68E+3nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703894(7-(2-chlorobenzyl)-4-methyl-1,5-naphthyridin-2- am...)
Affinity DataKd:  3.15E+4nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703894(7-(2-chlorobenzyl)-4-methyl-1,5-naphthyridin-2- am...)
Affinity DataIC50: 3.00E+5nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703894(7-(2-chlorobenzyl)-4-methyl-1,5-naphthyridin-2- am...)
Affinity DataIC50: 3.00E+5nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent