BDBM703843 (3R)-3-amino-7-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1,1-dioxo-5-[[4-(1,1,2,2-tetrafluoroethoxy)phenyl]methyl]-2,3-dihydro-1λ6,5-benzothiazepin-4-one::US20240368150, Example 442

SMILES CC(C)(C)c1nnc(-c2ccc3c(c2)N(Cc2ccc(OC(F)(F)C(F)F)cc2)C(=O)[C@@H](N)CS3(=O)=O)o1

InChI Key InChIKey=OSZHDOQYGZDHKM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 703843   

TargetDiacylglycerol kinase alpha(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM703843((3R)-3-amino-7-(5-tert-butyl-1,3,4-oxadiazol-2-yl)...)
Affinity DataIC50: 1.39E+3nMAssay Description:DGK α and ζ kinase use ATP to phosphorylate the substrate 1,2-dilauroyl-sn-glycerol (DLG, incorporated in the liposomes). ATP is converted to ADP as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

TargetDiacylglycerol kinase zeta(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM703843((3R)-3-amino-7-(5-tert-butyl-1,3,4-oxadiazol-2-yl)...)
Affinity DataIC50: 285nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent