BDBM703794 (3R)-3-amino-5-[(4- chlorophenyl)methyl]-8- fluoro-7-[5-(4-oxa-7- azaspiro[2.5]octan-7-yl)-1,2,4- oxadiazol-3-yl]-1-oxo-2,3- dihydro-1lambda4,5-benzothiazepin- 4-one (Epimer A) (*)::US20240368150, Example 211

SMILES N[C@H]1CS(=O)c2cc(F)c(-c3noc(N4CCOC5(CC5)C4)n3)cc2N(Cc2ccc(Cl)cc2)C1=O

InChI Key InChIKey=OGMRJLKQCVITHH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 703794   

TargetDiacylglycerol kinase alpha(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM703794((3R)-3-amino-5-[(4- chlorophenyl)methyl]-8- fluoro...)
Affinity DataIC50: 1.29E+3nMAssay Description:DGK α and ζ kinase use ATP to phosphorylate the substrate 1,2-dilauroyl-sn-glycerol (DLG, incorporated in the liposomes). ATP is converted to ADP as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

TargetDiacylglycerol kinase zeta(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM703794((3R)-3-amino-5-[(4- chlorophenyl)methyl]-8- fluoro...)
Affinity DataIC50: 330nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent