BDBM703790 (3R)-3-amino-5-[(4-chlorophenyl)methyl]-8-fluoro-7-[5-(2-oxa-5-azabicyclo[4.1.0]heptan-5-yl)-1,2,4-oxadiazol-3-yl]-1-oxo-2,3-dihydro-1λ4,5-benzothiazepin-4-one (Epimer A)::US20240368150, Example 207

SMILES N[C@H]1CS(=O)c2cc(F)c(-c3noc(N4CCOC5CC54)n3)cc2N(Cc2ccc(Cl)cc2)C1=O

InChI Key InChIKey=NWTYKFQHIZEKEK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 703790   

TargetDiacylglycerol kinase alpha(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM703790((3R)-3-amino-5-[(4-chlorophenyl)methyl]-8-fluoro-7...)
Affinity DataIC50: 6.25E+4nMAssay Description:DGK α and ζ kinase use ATP to phosphorylate the substrate 1,2-dilauroyl-sn-glycerol (DLG, incorporated in the liposomes). ATP is converted to ADP as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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TargetDiacylglycerol kinase zeta(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM703790((3R)-3-amino-5-[(4-chlorophenyl)methyl]-8-fluoro-7...)
Affinity DataIC50: 193nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent